Application of Nanoprecipitation Technique to Develop Poloxamer-407 Facilitated Solid Lipid Nanoparticles for the Controlled Delivery of Tacrolimus

Currently, the solid lipid nanoparticles (SLNs) are utilized as a novel approach for controlled drug delivery system (CDDS). Tacrolimus (TCM), lipophilic drug, can easily be encapsulated in hydrophobic core of these SLNs using nanoprecipitation technique. The current aim was to develop release Poloxamer (PLX) facilitated TCM loaded (PLX/TCM-SLNs), followed by their physicochemical evaluations, including chemical compatibility, particle size, surface charge, morphology, nature SLNs, loading efficiency (LE), entrapment (EE), vitro studies, kinetic modeling, and statistical evaluation. Here we also evaluate properties investigate solubility profile improvement dissolution rate PLX/TCM-SLNs. PLX used process polymer due its low toxicity weak immunogenic properties. prepared formulation characterized scanning electron microscopy (SEM) images, Fourier transform infrared spectroscopy (FTIR) has confirmed compatibility selected ingredients, whereas size analysis showed that PLX/TCM-SLNs were nanosized ( 120.6 ± 9 nm) having zeta potential −21.3 Mv. On other hand, SEM had revealed smooth uniform particle, while X-ray diffraction (XRD) crystalline structure masked. A satisfactory level EE id="M2"> 94.5 2.74 %) been noticed. Furthermore, studies have explored during 8 hours, following zero order kinetics diffusion type mechanism. Outcomes advocated successful preparation efficiently.